Cover Story：As the increasing aging population globally, Alzheimer’s disease (AD) has been the most common type of neurodegenerative disease, characterized with progressive cognitive impairment. The main pathological features were senile plaques, neurofibrillary tangles and neurons and synapse loss. Inhibitor of apoptosis family proteins (IAPs) are a class of endogenous apoptosis inhibitors, and their function in the pathological process of AD has not been clear. In this study, IAPs protein expression were analyzed from AD patient databases, AD animal models and brain slice models. NFκB signaling pathway was detected by EMSA and immunoblotting. The results show that Survivin acts as a co-upregulated gene in all models including AD patients, AD mouse models and Aβ, okadaic acid and LPS induced brain slices. NFκB signaling pathway was significantly activated, and they exhibited the similar expression profile. Therefore, the cell apoptosis in AD progression may be inhibited by NFκB/IAPs axis. Survivin may be an important target for AD prevention and treatment.