2018年第45卷第3期目录
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封面故事:生物成像技术在生物医学领域得到广泛应用,对医学临床实践、确定受疾病影响的定位、诊断人脑内部的肿瘤疾病起着十分关键的作用.现有的成像方法主要有脑电图、脑磁图、核磁共振成像,这些成像技术对医生诊断疾病起到协助作用,但是其空间分辨率有限,从而限制医生进一步诊断疾病成因.由于光的波长较短,与细胞内物质的尺度在同一数量级,光进入生物组织内部后会被严重散射,其进入生物组织的深度有限,因此难以实现对单个脑神经成像.通过对激光的空间位相分布进行调制,能够有效抑制生物组织对激光的散射作用,从而增加了生物成像的分辨率和光的穿透深度,能够实现深度生物组织成像,有望观察到单个脑神经.四元裂解位相调制算法较其他方法相比能够实现光通过生物组织成像的快速聚焦,解决了生物成像的分辨率问题,为提高生物成像深度提供了有效的途径.
(方龙杰,张熙程,张 诚,左浩毅,朱建华,高福华,庞 霖.光通过散射介质聚焦的空间位相逐个单元调节方法,本期第336~350页)
Cover Story:A method of focusing strongly scattered light through turbid media based on spatial light wavefront modulation was proposed in the field of biophysical imaging. The content and procedure of this new method was detailed described. The strict optical theory indicates that the focusing result is better if the effect of interference is considered more intensely. The experiment also indicates this phenomenon. In addition, the experiment reveals that under the same conditions, the more the number of pixels controlled on spatial light modulator, the better the focusing result is. This new method has higher signal-to-noise ratio than other methods. The result of focusing and the phase board uploaded on spatial light modulator are displayed in the paper. At the same time, the convergence rate of focusing is much faster than other methods. That is mainly because our method has considered interference and the focusing result is the superposition of all pixels modulated on spatial light modulator. Therefore, we think that it will provide a new idea for the research of biophysics imaging.
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综述与专论
研究报告
Letter to Editor
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