2020年第47卷第5期目录
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封面故事:扩散光学断层成像(DOT)是一种新兴的生物医学成像模态. 相较于传统的X射线、MRI等医学成像手段,其特有的无创、实时、高分辨率以及成像成本低廉等优势受到了广泛的关注. 目前这一技术已经应用于临床诊断治疗和科学研究等重要领域. 苏黎等在原有系统基础上,通过自主设计研发新设备,替换原有性能冗余、成本高昂的部件,使得系统成本下降了40%以上,并提升了集成化程度. 通过将传统手工技术与现代3D打印技术相结合,全新设计制作出了一款方便实用、应用范围广泛且佩戴舒适的脑机接口(BCI). 此外,本研究首次将3D激光扫描仪应用于待测物解剖结构信息获取,并与计算机辅助工程(CAE)软件结合,生成出了用于图像重建的有限元网格数据. 通过以上手段的结合,在人脑形状仿体实验中成像深度达到了35 mm. 这一结果表明,该系统将在人脑乃至人体全身各部位成像研究中发挥重要作用.
(苏 黎,熊志豪,杨浩,黄林,蒋华北. 一种低成本、高性价比的穿戴式扩散光学断层人脑成像系统,本期第439~447页)
Cover Story:Current diffuse optical tomography (DOT) systems often adopt premium photo detectors and amplifiers, thus leading to a high cost and low performance-to-price ratio to the system. The aim of this work is to investigate the use of novel techniques to reduce the cost of system, increase the imaging depth and develop a new DOT system for practical human brain imaging. In this paper, low-cost photo detectors and a self-developed photodiode pre-amplifier were employed. Comparing to the previous system of our laboratory, the whole cost of the new system was cut by more than 40% . Next, we designed a wearable fiber-free brain computer interface (BCI) which is flexible and can fit well with subjects featuring different shapes. A handheld 3D laser scanner was initially used to accurately acquire the shape of subjects and the locations of sources and detectors in this work. Finally, the imaging depth of targets was up to 35 mm of the new system in human head-shaped phantom experiments performed with the integrated application of techniques and instruments as mentioned above. This validated result demonstrates that our new system has gained the ability for function real human brain imaging.
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综述与专论
研究报告
技术与方法
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