2022年第49卷第11期目录
|
|
封面故事:神经元丢失是各类中枢神经系统疾病中非常重要的病理过程,解决神经元丢失的问题
能够为中枢神经系统疾病带来曙光。其中,近期受到广泛关注的一种神经再生的方法是将大脑中
原本存在的神经胶质细胞(包括星形胶质细胞、小胶质细胞、NG2胶质细胞等等) 转分化为神经
元,从而补充疾病中丢失的神经元,改善甚至扭转中枢神经系统疾病的进程。近年来,学者通过
在神经胶质细胞中将神经元命运决定的重要转录因子过表达或敲减等手段,成功实现其向神经元
的转分化,取得多项重大进展,但由于目前研究手段的局限、判断标准的分歧、结果和结论间较
难自洽等问题,部分研究成果的结论仍存在很大的争议。赵晓初等介绍了目前神经胶质细胞-神经
元转分化领域的重要发现,并进行了讨论和展望。
(赵晓初,罗兆莉,杨菲,李纤. 神经胶质细胞转分化为神经元的研究进展,本期第2087~2098 页)
Cover Story:Cellular conversion is a process of genetic reprogramming by various methods to induce the direct transformation of one type of cell into another without going through other intermediate states. Neuronal loss is a common pathological process in a variety of neurological disorders, including Parkinson’s disease, Alzheimer’s disease, and stroke. Neuronal loss is usually irreversible and causes motor, sensory, and psychiatric symptoms. Since the human central nervous system has limited capacity for neuronal regeneration, therapeutic strategies that use glial cells (astrocytes, microglia, and oligodendrocyte precursor cells) to transdifferentiate into functional neurons in situ of neuronal loss and integrate them into neural networks have received much attention. In recent years, successful conversion of glia-to-neuron by manipulating the gene expression of key transcription factors in neuronal fate determination in glial cells has been discovered. Nevertheless, there is still some controversy about the scientific validity of some research technologies, the rationality of judgment criteria, and the self-consistency between experimental results and conclusions. This article reviews the discovery and development of glia-to-neuron conversion and takes astrocytes, microglia, and oligodendrocyte progenitor cells as examples to summarize the important findings of glia-to-neuron conversion with discussion and perspective.
|
神经胶质细胞研究专刊
|
|