为了弄清血红蛋白A2现象的发生机制,我们对“红细胞HbA2”的化学组成进行了分析。“红细胞HbA2”的双向电泳结果表明,它含有两种血红蛋白成分:一种相当于HbA,另一种很可能是溶血液HbA2。其单向二次电泳结果也证明,它是由溶血液HbA2和HbA所组成。结果初步说明,盘红细胞中HbA2可能与HbA结合存在。两者可能有相互作用,也许这是产生血红蛋白A2现象的原因。
1. Chemical composition of erythrocyte HbA2 was analyzed in order to clarify the mechanism of hemoglobin A2 phenomenon. The paper reports the hemoglobin composition of erythrocyte HbA2.2. The results of two-dimensional electrophoresis showed that erythrocyte HbA2 contains two Hb components: one corresponds to HbA and the other most probably is hemolysate HbA2.3. The results of one-dimensional re-electrophoresis showed definitly that erythrocyte HbA2 is composed of hemolysate HbA2 and HbA.4. Tentative conclusion: HbA2 may be combined with HbA in erythrocyte, i.e. there is probably interaction between the two hemoglobins. This is perhaps the possible cause of hemoglobin A2 phenomenon.
秦文斌.血红蛋白A2现象发生机制的研究——“红细胞HbA2”为HbA2与HbA的结合产物[J].生物化学与生物物理进展,1991,18(4):286-289
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