Lipid peroxidation may lead to base modification,DNA strand breaks and formation of various fluorescent products in model systems,bacteria and eucaryotic cells.and the selective destruction of the base guanine in DNA.The transient metal ions can intensify the DNA damage obviously.Antioxidants and free radical scavagers have the protective effect of varying degrees for DNA damage induced by lipid peroxidation.8-Hydroxyguanine,which is strongly implicated in mutagenesis and carcino-genesis. has been observed.The molecular mechanism of mutagenesis and carcinogenesis induced by lipid peroxidation aroused great concerns in the field of free radical biology.