作为能使蛋白激酶C(PKC)活化的第二信使甘油二酯(DAG)不仅可由磷脂酰肌醇(PtdIns)水解产生,大量实验表明还可从磷脂酰胆碱(PC)水解而来,其中磷脂酶C(PLC)及磷脂酶D(PLD)参与了这一过程,磷脂酶A2(PLA2)的作用产物脂肪酸(FA)也能激活PKC.PKC至少有10种亚型,依据其活化方式可分三大类:典型PKC,新PKC和非典型PKC.PKC参与了基因表达的调控.
Diacylglycerol (DAG), as the second massenger to activate protein kinase C (PKC), may be derived not only from hydrolysis of phos-phatidylinositol (PtdIns), but also from hy-drolysis of phosphatidylcholine (PC) , in which phospholipases of the type C and D (PLC andPLD ) participate . Fatty acids (FA), the pro-ducts of phospholipases A2(PLA2) also acti vates PKC. PKC has at least 10 subspeciesand 3 group, namely classical PKC, new PKC and atypical PKC. PKC also participates inregulation of gene expression.
杨彧,于秉治.蛋白激酶C研究的最新进展[J].生物化学与生物物理进展,1994,21(4):308-312
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