BTF2,又称TFⅡH,为一多亚基蛋白质复合物,具有解链酶、依赖DNA的ATP酶及磷酸激酶活性,参与mRNA转录起始以及与转录偶联的核苷酸切除修复过程,在转录起始复合物形成过程中,BTF2/TFⅡH在有TFⅡE存在时,可使RNA聚合酶Ⅱ的羧端区域(CTD)、TBP及有关转录因子磷酸化.磷酸化反应可影响转录起始复合物中的蛋白质-蛋白质相互作用,调节转录起始,因此,BTF2/TFⅡH是一种重要的基本转录因子.
BTF2,also named TFⅡH, with multiple subunit complex is believed to have helicase,DNA-dependent ATPase and phosphate kinase activities paticipated in transcription initiation and transcription-coulpled nucleotide-excision repair.During the formation of transcription initiation complex,polymerase ⅡC-terminal domain(CTD),TBP and associated transcription factors are phosphorylated by BTF2/TFⅡH in the presence of TFⅡE.These phosphorylation modifications can be expected to have effects on the regulation of transcription initiation through affecting protein-protein interactions. So BTF2/TFⅡH is an important transcription factor in eukaryotic cells.
倪菊华,贾弘禔,张迺蘅. BTF2/TFⅡH的多功能与PolⅡ转录[J].生物化学与生物物理进展,1995,22(6):491-494
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