cGMP作为胞内第二信使,主要通过cGMP依赖的蛋白激酶(cGPK),cGMP门控的离子通道,cGMP调节的环核苷酸磷酸二酯酶以及ADP核糖环化酶等后续途径,参与许多细胞功能的调控.cGMP既可以通过蛋白磷酸化,也通过与蛋白磷酸化不直接相关的信号传递途径来调控各类细胞的特定生理功能.
As an important intracellular second messenger,cyclic GMP regulates various functions of cells,such as visual and olfactory signal transduction, vascular smooth muscle relaxation,lymphocyte activation and chemotaxis of reproductive cell.In different kinds of cells,cyclic GMP interacts with cGMp-dependent protein kinases,cGMp-regulated ion channels,cGMp-regulated cyclic nucleotide phosphodiesterases or ADP-ribosyl cyclase respectively.This means that cyclic GMP can regulate cell functions through protein phosphorylation or through pathways not directly related to protein phosphorylation. It appears that the regulatory mechanisms of cyclic GMP are variable and related to the specific subcelluar structure.
毛俊浩,吕志良. cGMP对细胞功能的调控[J].生物化学与生物物理进展,1995,22(6):511-516
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