Recent Advances in interleukin-2 Receptor γ Chain Research
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摘要:
白细胞介素－2受体γ链（interleukin-2 receptorγchain，IL-2Rγc）是约3年前发现的IL-2受体亚单位之一，它不但参与高、中亲和力IL-2R的形成，而且作为细胞因子受体超家族成员参与IL－4、IL－7、IL－9和IL－15受体以及可能的IL－13受体功能性复合物的形成．IL-2Rγc基因结构与功能和蛋白质分子结构以及染色体定位已阐明．IL-2Rγc及信号传导的异常导致人类Ｘ染色体连锁重度联合免疫缺陷病(X-linked severe combined immunodeficiency XSCID)．因此，阐明IL-2Rγc在生理及病理状态下的生物学作用，对了解淋巴细胞的生长发育和分化成熟、免疫应答及其调控等问题都有重要的指导意义．
Abstract:
Interleukin-2 receptorγchain(IL-ZRγc)is one of IL-2R subunits discovered about three years ago. It not only participates in the formation of high and medium affinity IL-2R complex, but also join in the formation of functional complexes of IL-4R,IL-7R,IL-9R and IL-15R, possibly IL-13R, serving as a member of cytokine receptor super family. IL-2Rγc gene's structure and function, the molecule structure and chromosome mapping have been elucidated. Abnormalities of IL-2Rγc and its signaling result in human X-linked severe combined immunodeficiency(XSCID).It is significant to explain the biological properties of IL-2Ryc in physiological and pathological condi-lions to understand the development, maturation and differentiation of lymphocytes and immunoresponse etc.
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