在自然或人为创伤和感染情况下,昆虫能迅速产生各种类型的抗菌因子,例如天蚕素(cecropin),果蝇抗菌蛋白(diptericin),天蚕抗菌蛋白(attacin)和防御素(defensin)等.这些活性多肽和蛋白从其被合成的脂肪体和某些血细胞中,分泌到血淋巴参与虫体对入侵物的免疫反应.抗菌多肽和蛋白的诱导、表达及其协同作用于外源微生物,构成昆虫先天性防卫免疫系统中极为重要的环节.近年的研究表明,昆虫的这种防卫免疫系统与哺乳动物急性期反应是相关的,特别是在有关基因表达的协调控制方面具有许多共同的基本特征.
In response to bacteria or trauma, insects produce a battery of antibacterial peptide or polypeptide such as cecropin, diptericin, attacin and defensin, the synthesis of which are induced in the fat body and secreted into the hemolymph where they act synergistically to kill the invading microorganisms. The insect host defence system shares common basic characteristics of the mammalian acute phase response, especially in the aspect of the coordinating gene expression, where similar cis-regulatory and inducible transactivator appear to play major roles.
屠益增,蔡敏莺,屈贤铭.昆虫抗菌蛋白基因转录调控研究的新进展[J].生物化学与生物物理进展,1997,24(1):22-26
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