细胞内自由钙作为一种重要的细胞信使广泛地参与细胞生理功能调控.胞内钙库(内质网系和肌浆网系)对调节细胞内自由钙水平起着重要的作用.钙库膜上的钙释放通道(ryanodine受体和三磷酸肌醇受体)受许多因素调控,其中之一就是新近研究得相当多的FK506结合蛋白.免疫抑制剂FK506能特异地结合钙库上一种分子质量为12 ku左右的蛋白,这种FK506结合蛋白与钙释放通道形成一种紧密连接的复合体,在正常生理情况下对钙释放通道起着十分重要的调控作用.
As an important messenger, intracellular free calcium can modulate many cellular functions. Calcium stores, endoplasmic reticulum and sarcoplasmic reticulum, play important functions in controlling the level of intracellular calcium. The activities of calcium release channel on these calcium stores, ryanodine receptor and inositol trisphosphate receptor, are affected by several factors. FK506, an immunosuppressive drug, can specifically bind to a cytosolic receptor with molecular weight of about 12 ku, namely, FK506-binding protein (FKBP12). In vivo, FKBP12 maintains a tight association with calcium release channel and forms a complex. This interaction plays important roles in modulating calcium release channels.
孙俊辉,朱培闳. FK-506结合蛋白对钙释放通道的调控[J].生物化学与生物物理进展,1997,24(5):418-422
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