前列腺素A2(PGA2)具有强的体内、外抗增殖活性,引起细胞周期阻滞,同时,可诱导cdk抑制物p21蛋白的表达,后者亦可介导多种细胞的G1阻滞.提示p21waf1/cip1在PGA2诱导的细胞周期阻滞中具有重要作用.主要介绍了近两年来有关p21waf1/cip1与转录因子E2F间的相互作用的研究,阐述p21waf1/cip1在PGA2介导的细胞周期阻滞中的作用机制.
The cyclopentenone prostaglandin A2 (PGA2) exhibits potent antiproliferative and antitumor activities both in vitro and in vivo, leading to cell cycle arrest associated with a dramatic decrease in the levels of cyclins and cyclin-dependent kinases(CDKs), and accompanied by an obvious increase of the expression of one of the cdk inhibitors, p21waf1/cip1. p21 waf1/cip1 protein(p21) can also mediate p53 dependent or p53-independent G1 arrest of many cell types, and plays an important role in PGA2-induced cell cycle arrest. Latest progress on the role of interaction of p21 and transcription factor E2F played in PGA2-mediated cell cycle arrest is reviewed.
董为人,彭必友,李进. G1阻滞中p21-E2F间的相互作用[J].生物化学与生物物理进展,1997,24(6):506-510
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