Tenascin-R (TN-R) is an important extracellular matrix glycoprotein. Tenascin-R is restricted to the central nervous system and mainly express in the early developing of oligodendrocytes. It also expreses in mature oligodendrocytes and some neural cell types (Such as spin cord. optic nerve, inter neuron of cerebellum and hippocampus).Tenascin-R has a modular structune with a cysteine-rich amino-terminal region followed by epidermal growth factor (EGF)-like repeats(EGF-L), fibronectin-typeⅢ homologous repeats(FNⅢ) and a fibrinogen like domain at the carboxy-terminal end.Tenascin-R has perplexing multifunctionality. Tenascin-R acts as a repellent molecule for neuron, promotes or inhibites the outgrowth of neurite,induces a polarity morphology of neurons and relates to myelinating processes. Tenascin-R has multiple receptors. F3/F11, XL1, Xprocan and MAG which have been isolated and characterized.