By use of the AR-CM-MIC system and other methods, the relationship between cellular viability of alveolar macrophages and the change of intracellular Ca²⁺ concentration(［Ca²⁺］_i) after the action of verapamil was investigated under different extracellular calcium concentrations. And the research about the effect of verapamil on experimental silicosis rats were conducted. The results showed: the ［Ca²⁺］_i rise induced by α-quartz was caused by enormous extracellular Ca²⁺ influx and the overloading of the intracellular Ca²⁺, which directly led to the death of alveolar macrophages and further the formation of silicosis. Verapamil could inhibit the ［Ca²⁺］_i rise, decline the death of cells. The results of the research about experimental silicosis indicated: verapamil has apparent inhibitory effect on the starting of silicosis. It suggested that verapamil appears to be a prevention and cure drug of silicosis.