酪氨酸激酶受体(RTK)参与细胞生长、分化、胚胎发育及细胞内信号传递等过程,具有相当重要的生理功能.目前已发现50多种RTK基因分属于14种亚族,Eph亚族是其中最大的家族,由14个基因组成,一些基因主要在脑的发育中表达,另一些则在各种组织中广泛表达.最近该亚族胞外配体的发现为深入研究其生理功能打下基础.综述了Eph亚族成员的来源、表达及其配体的研究概况.
Receptor tyrosine kinases (RTKs) are involved in many different processes including cellular growth,differentiation,embryonic development,oncogenesis and intracellular signalling pathways, thus possessing important physiological functions. There are now more than 50 distinct RTK genes that have been published and divided into 14 sub-families ,the largest one known is the Eph sub-family which is comprised of at least fifteen members. Some of the Eph family members are predominantly expressed in the developing brain, the others are expressed in a broader range of tissues. Recently the findings of the excellular ligands of this family should facilitate further studies of its function. The isolation, pattern of expression and the ligands of Eph-like receptors are summarised.
张晓光,药立波,苏成芝.酪氨酸激酶受体Eph亚族的研究进展[J].生物化学与生物物理进展,1999,26(1):15-19
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