The gene zif268 codes for a transcription factor ZIF268. The expression pattern of zif268 in developing visual cortex is regulated. zif268 is highly expressed in adult visual cortex which experienced normal visual input. After visual deprivation, the expression level of zif268 is strongly down-regulated, while visual stimulation can significantly increase the expression level of zif268. The studies concerning the expression pattern of zif268 offer further insight into the physiological functions of zif268 in the mammalian visual system.