Integrins are cell adhesive molecules (CAMs) comprised of α and β subunits. These CAMs usually contain a large domain, a transmembrane segment and a short cytoplasmic domain. They can interact with the extracellular matrix components, such as collagen, fibronectin, or vitronectin, to regulate the cell adhesion and trafficking. As a bidirectional transducer, integrins are involved in cell signaling by way of inside-outside signaling and outside-inside signaling. Successful implantation depends on the intimate interaction between the penetrative blastocyst and the receptive endometrium, which contains many cellular or molecular events. More recently, accumulating evidences have shown that expression of integrins during the “implantation window” stage plays an important role in “maternal-fetal dialogue” and becomes a potential marker of the receptive uterine endometrium.