Advances in Research of p185 Protein and Its Antibodies
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摘要:
描述了p185在信号转导过程中的功能，讨论了抗p185抗体的蛋白质工程及它们在肿瘤治疗中的应用.
Abstract:
p185neu/c-erbB-2 is a receptor tyrosine kinase. It's overexpressed in some adenocarcinomas, such as breast cancer and ovary cancer. It not only plays an important prognostic role, but also acts as a therapeutic target in breast cancer. Its function in signal tranduction is described. The protein engineering of antibodies against p185 and their application in cancer therapy is also discussed.
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