近年来,N-甲基-D-门冬氨酸(NMDA)受体在突触可塑性形式——长时程增强(long-term potentiation,LTP)中的作用及该受体被激活后的细胞内级联反应备受人们的关注.人们利用拮抗剂技术和基因敲除的方法,对其进行了广泛的研究,并且就LTP的诱导和维持方面获得了一些进展.已获得的这些研究结果为LTP的突触前及突触后机制提供了有力的证据.
In recent years, the effects of the N-methyl-D-aspartate(NMDA) receptor on the long-term potentiation(LTP) and the intracellular cascade reaction after the activation of the NMDA receptor are emphasised widely by people through antagonists and gene knockout technique. These studies show the processeing of induction and maintenance of the LTP. The results provide evidences for the pre- and post-synaptic mechanism of the LTP.
朱洪波,罗建红. NMDA受体和长时程增强[J].生物化学与生物物理进展,1999,26(6):541-543
复制生物化学与生物物理进展 ® 2024 版权所有 ICP:京ICP备05023138号-1 京公网安备 11010502031771号