阿尔茨海默氏病(Alzheimer's disease,AD)是一种神经退行性疾病,是老年人群痴呆最普遍的原因,也是老年人病态和死亡的主要原因.以阿尔茨海默氏病与氧应激为题,从AD发生的分子基础和氧应激基础,以及β淀粉样蛋白(β amyloid, βA)的聚合作用和毒性与自由基的关系,对近年来在AD发生机制研究中引人注目的氧应激问题,作一简要综述.
Alzheimer's disease(AD) is a neurodegenerative disorder.It is the most common cause of dementia in aged population and also a main cause of death in aged people.The oxidative stress hypothesis of AD has focused on and described from four aspects:Molecular basis and oxidative stress basis of AD pathogenesis,and β amyloid aggregation and cytotoxicity related to reactive oxygen species.
陈瑗,周玫.阿尔茨海默氏病与氧应激[J].生物化学与生物物理进展,1999,26(6):547-551
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