近年来有关细胞内信号传导的研究,着重体现在Ca2+信号传导途径及相应的蛋白质分子如蛋白激酶C(PKC)、钙调素(CaM)、钙调素激酶Ⅱ(CaMKⅡ),同时也对Ras途径中出现的Vav、Rap、Crk、C3G等蛋白质分子以及cAMP和NF-κB途径作了有益的补充与修改.细胞外信号分子通过以上4种途径及其相互通讯(cross-talk),激活了某些蛋白激酶,调控了基因转录及其他相关功能,其中磷酸化对蛋白激酶及转录因子活性的调节起到了非常重要的作用.
The latest development on intracellular signal transduction mainly focus on Ca2+ pathways with their related protein molecules such as PKC,CaM,CaMKⅡ,and Ras with their related protein molecules(such as Vav,Rap,Crk,C3G),cAMP,NF-κB pathways as well. Through the above mentioned four pathways and the cross-talk among them,extracellular signal molecules activate some protein kinases which regulate gene transcription and other related functions.It should be noted that phosphorylation plays a significant role in regulating the activity of protein kinases and transcript factors.
庞飒,龚兴国.细胞内信号分子传导的研究进展[J].生物化学与生物物理进展,2000,27(1):24-28
复制生物化学与生物物理进展 ® 2024 版权所有 ICP:京ICP备05023138号-1 京公网安备 11010502031771号