Caspases是一类天冬氨酸特异性的半胱氨酸蛋白酶(IL-1β转化酶相关蛋白酶).迄今,在哺乳动物至少已发现13种caspase成员.Caspases在胞内通常以无活性的酶原形式存在,在其内部特定的天冬氨酸残基部位蛋白质裂解加工后可导致酶原激活,引发细胞凋亡.作为效应子的caspase在绝大多数细胞的凋亡过程中具有十分重要的作用.随着线虫死亡程序及某些死亡受体介导敏感细胞凋亡的信号机制的阐明,人们对caspase激活与调控在细胞凋亡中的机制研究已获得重大进展.
Caspase is a rapidly growing family of aspartate-specific cysteine proteases(interleukin 1β-converting enzyme related proteases).Up to date,thirteen mammalian caspases have been discovered.Caspases normally exist in cells as inactive proenzymes.Caspases proteolytic processing at aspartate specific sites unleash their latent enzymatic activity and trigger cell apoptosis. Caspase as effector plays an important role in most cell apoptosis. Big progress was maded for the molecular mechanism of caspase activation and regulation in cell apoptosis.
熊世勤,朱锡华. Caspase激活与调控的分子机制[J].生物化学与生物物理进展,2000,27(1):33-37
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