By mediating and regulating of apoptosis in macrophages themselves and other cells as well, macrophages carry out their function in immunology and immunological regulation. The macrophage apoptosis inducing factors were of biologic, chemical, pathologic. Some distinguished features characterized macrophage apoptosis and its regulation. Interestingly, to fit in with need of the body, macrophages may mediate or inhibit apoptosis in themselves, favour or inhibit apoptosis of other cells, inhibit apoptosis in themselves and favoured apoptosis of others, which may be the base for macrophages play a role in immunological regulation, especially in tumor immunology.