This work was supported by a grant from Ministry of Education of China.
TALL-1是TNF家族成员中最近发现的一个新型细胞因子,由单核细胞和巨噬细胞产生. 人TALL-1由285个氨基酸残基组成,而鼠TALL-1由309个氨基酸残基构成,两者均为Ⅱ型穿膜蛋白质. 人sTALL-1是长为152个氨基酸残基的胞外区片段,对应于C端134~285位氨基酸残基. 重组人sTALL-1具有刺激B细胞增殖、激活NF-κB和JNK以及抑制肿瘤细胞生长等生物学活性. 另外,TALL-1在转基因鼠中的过量表达可引起严重的B细胞增生以及与狼疮有关的自身免疫性疾病. 因此,TALL-1是一个具有多种生物学活性的细胞调控因子.
TALL-1(tumor necrosis factor and apoptosis ligand-related leukocyte-expressed ligand 1), a member of the TNF family, is a novel cytokine identified recently. The human and mice TALL-1 consist of 285 and 309 amino acids, respectively. It was shown that TALL-1 is a type Ⅱ transmembrane protein which is produced in monocytes and macrophages. A soluble form of human TALL-1(sTALL-1) has a extracellular domain composed of 152 amino acids which corresponds to C-terminal 134~285 site of amino acids. The recombinant human sTALL-1 is functionally involved in stimulating B cell growth, activating NF-κB(nuclear factor-kappa B) and JNK(c-Jun NH2-terminal kinase), and inhibiting tumor cell growth. Moreover, the overexpression of TALL-1 in transgenic mice can result in severe B cell hyperplasia and autoimmune lupus-like disease. Therefore, TALL-1 functions as a potent regulatory factor in vivo and in vitro.
刘存仁. TNF家族成员TALL-1及其研究进展[J].生物化学与生物物理进展,2001,28(4):490-493
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