The nearly close of sequencing stages of the various genome projects transforms structural biology into structural genomics. Structural genomics is the systematic determination of all genome products' structures. It uses high-throughput selection, expression, purification, structure determination and computational analysis to provide an experimental structure or a good model for every protein in all completed genomes, that will accelerate scientific study in all areas of biological science. The developments of bioinformatics, gene engineering and structure determination techniques provide the guarantee for structural genomics. Recent developments in the technology of nuclear magnetic resonance make it as a key method of high-throughput structural analysis in structural genomics.