外切体是酿酒酵母中鉴定的一个保守复合体,具有3′外切核酸酶的活性.10个核心亚基,除Csl4p/Ski4p外,在体外都具有3′外切核酸酶的活性.外切体在多种RNA的代谢中起重要作用.外切体普遍存在于真核生物中,并与真核基因的表达调控密切相关.
The exosome is a conserved complex which identified in Saccharomyces cerevisiae and has 3′ exoribonuclease activity in vitro. The exosome contains ten core subunits, and all except Csl4p/Ski4p are 3′ exoribonucleases in vitro. The exosome acts important role in several pathways of RNA metabolism. The exosome is a universal complex in eukaryote and is related to expression of eukaryotic genes.
王树启,王金发.外切体研究进展[J].生物化学与生物物理进展,2002,29(1):10-13
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