国家重点基础研究发展规划项目(973)(G19980512)和国家自然科学基金重大项目(39990570)资助.
This work was supported by grants from National Natural Sciences Foundation of China (39990570).
钙/钙调蛋白依赖性丝氨酸蛋白激酶(calcium/calmodulin-dependent serine protein kinase, CASK)属于膜相关鸟苷酸激酶(membrane associated guanylate kinase, MAGUK)家族.CASK具有多个不同蛋白质结合结构域,在细胞膜的特定区域,与其他蛋白质形成多种蛋白质复合体,参与组成细胞骨架.它通过衔接细胞外信号蛋白和细胞内骨架蛋白,协助功能蛋白质的转运和定位,以及细胞内的信号传递.此外CASK还可以进入细胞核影响基因转录调控,以及作用在神经突触膜上参与神经递质的释放.
Calcium/calmodulin-dependent serine protein kinase(CASK)is a member of membrane associated guanylate kinase (MAGUK) family. CASK has multiple protein-binding domains which can interact with other kinds of proteins. CASK acts as a molecular scaffold organizing multiprotein complexes at special areas of the plasma membrane. Mediating a direct link between extracellular matrix and actin cytoskeleton of plasma, CASK might help some proteins to localize to the functional places and be involved in multiple functions of signal transduction, neurotransmitter release in the synapses, nuclear translocation, and transcriptional control.
刘煜,赵晓航,吴旻.钙/钙调蛋白依赖性丝氨酸蛋白激酶的结构和功能[J].生物化学与生物物理进展,2002,29(1):14-18
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