国家自然科学基金(2001939)和中国科学院生物技术特别支持基金的资助(STZ-01-08).
This work was supported by grants from the National Natural Foundation of Sciences (2001939) and Life Science Special Fund of CAS Supported by the Ministry of Finance (STZ-01-08).
从分子生物学的角度而言,胚胎发育就是基因的时空调控过程,从而构建动物的三维模式.顺式调控是发育基因的基本原理;转录调控因子的激活与抑制决定了细胞分化与结构形成.
In the view of molecular biology on morphogeny of a three-dimensinal embryo, morphogenesis and development are dependent upon activation of transcription of involving genes followed by the inactivation in a specific part of embryo at a certain time. It has been demonstrated that cis-acting elements of genes can act to provide sharply defined patterns. Simultaneously, it is accepted as an important mechanism that both activation and repression of transcription factors are closely related to cell differentiation and morphogenesis.
许亚杰.基因转录调控与早期三维生命体模式的构建[J].生物化学与生物物理进展,2002,29(2):180-183
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