The low-affinity neurotrophin receptor p75 plays an important role during retina development and regeneration. But its localization in human retina has not been explored till now. The expression of p75 in human retinae from embryonic 5 to 7-month old was studied using immunohistochemistry method under light microscopic level. The most intensive p75 immunoreactivity appeared in ganglion cell layer, and weak p75 reactivity also presented in other part of the retina. In the retina of 6 and 7-month old embryos, relative strong p75 immunoreactivity appeared in inner limiting membrane, which is formed by the end-feet of Müller cells. The result indicates that, like in rat retina, p75 mainly localized on Müller cell processes though the possibility of p75 on retinal ganglion cells could not be completely excluded.