nogo is a recently discovered gene. It mainly encodes three proteins: Nogo-A, Nogo-B and Nogo-C. To date, it has been proved to be associated with axonal outgrowth inhibition in mature central nervous system(CNS) and apoptosis-inducing. Nogo receptor is a glycosylphosphatidylinositol(GPI)-anchored protein. To investigate the Nogo and Nogo receptor is important for understanding of neurite outgrowth inhibition following CNS injury and cancer.