Baculoviruses are host specific for insects. The recent researches indicated that baculoviruses could entry into different mammalian cells, but do not replicate. The baculoviruses have been successfully used to deliver foreign DNA into mammalian cells in vitro and in vivo and efficiently mediated the expression of interest genes. These results indicated that baculovirus could be developed as potential gene therapy vectors. The recent development and prospects on using baculoviruses as target gene delivered vectors in gene therapy is reviewed.