This work was supported by grants from The Special Funds for Major Research Program of Guangdong Province (2KM04205S) and the Special Funds for Major Subject Program of Guangdong Province (9906).
近来,人类发现了一些不同种类的小RNA分子,其中miRNA是人类新发现的一类小RNA,它在进化上具有保守性,在数量、序列、结构、表达和功能上具有多样性.目前,大约已发现了100多种miRNA,它们存在于不同的生物中,从四膜虫、线虫、植物、动物到人都已发现了不同的miRNA.miRNA的主要功能是调节内源基因表达,它在基因活动调控网络中扮演了重要的角色.miRNA与siRNA关系密切,它们既具有相似性,又具有差异性.小RNA分子研究将是今后分子生物学的研究热点之一.
MicroRNAs (miRNA) belong to a novel large family of short single-stranded conserved noncoding regulatory RNAs that include the small temporal RNAs lin4 and let7. They exhibit a diversity in sequence, structure, abundance, and expression profile. There are similarities and differences between miRNAs and another class of RNAs called short interfering RNAs (siRNA). The recent advance of miRNAs is reviewed.
李继霞,周克元. miRNA的研究进展[J].生物化学与生物物理进展,2003,30(5):702-705
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