Adipose tissue is not only an energy storage organ but also an important endocrine organ. It assists nerve system and other endocrine organs to maintain body homoeostasis. In recent years, some studies suggested a tight relationship between adipose tissue and immunity. Leptin, a hormone secreted by mature adipocyte which functions in regulating not only energy metabolism and body fat mass but also the immune effects of monocyte, macrophage, and lymphocytes. Adiponectin, another factor secreted by adipose tissue，can also regulate the immune responses of cells. In addition, immune stimulation can induce lipolysis of fat depot around lymph node. The interaction between adipocyte and immune system further demonstrates that the living body is an intergrated organic unity. The advancement in this area of study would likely provide new perspectives to therapeutic methods on related diseases.