This work was supported by a grant from The Hundred Talent Program, The Chinese Academy of Science(038).
Notch 信号通路为一广泛应用且高度保守的信号转导途径,决定多能祖细胞的分化方向,其中在共同淋巴祖细胞向 T 淋巴细胞或 B 淋巴细胞分化选择中具有决定性作用 . Notch 信号通路参与淋巴细胞的发育过程,促进 Tαβ细胞的形成、诱导处女型 T 细胞变为调节型 T 细胞、阻止 CD4+T 细胞向 Th1 类型分化,以及增加外周免疫器官边缘区 B 细胞的数量 . 在分析 Notch 蛋白结构的基础上,综合最新进展,系统阐明了 Notch 信号通路的组成、作用机制、参与的淋巴细胞发育过程以及所起的作用 .
The Notch pathway is a wildly utilized, evolutionarily conserved regulatory signaling pathway that plays a central role in the fate decisions of multipotent precursors including common lymphoid precursors, which will undergo either T or B cell differentiation. Notch signaling participates in the process of lymphocyte development. It can promote formation of Tαβ cells, induce development of regulatory T cells from na?ve T cells, and block CD4+ T cell to differentiate to Th1 cell. It can increase the numbers of MZB cells. On the basis of structure of Notch and the new progress on Notch, the role of Notch signaling in the process of lymphocyte development and its molecular mechanisms have been reviewed.
孙丽光,孙祖玥,龚守良,赵 勇. Notch 信号通路与淋巴细胞发育[J].生物化学与生物物理进展,2005,32(10):917-923
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