Glucocorticoid modulates multiple important physiological and pharmacol- ogical processes, in addition to the classic genomic model of glucocorticoid action. Recent evidence suggests more and more important role of nontranscriptional effects. Receptors, kinases and signal molecules may be involved in nongenomic pathway. Despite the many differences between genomic and nongenomic pathways, cross-talks between each other might occur. Therefore, the research of nongenomic mechanism will make for the reasonable clinical application of glucocorticoid.