国家自然科学基金(30570957)和河北省自然科学基金(C2006000152)资助项目.
This work was supported by grants from The National Natural Science Foundation of China (30570957) and The Provincial Natural Sciences Foundation of Hebei Province (C2006000152).
小鼠24p3是脂质运载蛋白lipocalin家族的成员之一,可在白介素3 (interleukin-3,IL-3) 缺乏时诱导细胞发生凋亡,并参与细胞的铁转运过程. 最近,Devireddy等又成功克隆到了24p3的细胞表面受体 (24p3 receptor,24p3R),进一步确定了24p3-24p3R这一新的铁转运途径. 该途径的发现不仅增加了对铁转运理论新的认识,更重要的是,这一发现为铁代谢调控细胞凋亡理论的建立奠定了基础.
The 24p3 of mouse is a member of lipocalin family and it has been implicated in iron transport and apoptosis due to interleukin-3(IL-3) deprivation. Devireddy and colleagues cloned the receptor of 24p3 and further confirmed that the pathway of 24p3-24p3R is a new iron transport approach in Dec 2005. A link between iron internalization mediated by 24p3R and regulation of apoptosis was suggested.
赵颂民,石振华,段相林,常彦忠.24p3-24p3受体系统:一种新的铁转运途径[J].生物化学与生物物理进展,2007,34(6):557-561
复制生物化学与生物物理进展 ® 2024 版权所有 ICP:京ICP备05023138号-1 京公网安备 11010502031771号