Transmenbrance serine proteases 6(TMPRSS6) is a recently identified transmembrane serine protease, this protein regulates the expression of hepcidin in the process of iron metabolism, thereby affecting the body of the iron steady. The discovery of TMPRSS6 is not only very important to the understanding of mechanism of iron metabolism but also reveals the etiology of iron metabolism-related diseases, it provides a new way of thinking about how to treat these diseases.