Epigenetics indicates the heritable changes in gene expression without nucleotide sequence variation. The process of epigenetic regulation is very complex, which mainly includes DNA methylations, histone modifications and miRNA. Diabetes is a chronic metabolic disease accompanied with macrovascular and microvascular complications. The development of diabetes not only depends on genetic factors, but also is regulated by epigenetic regulation. Therefore, further exploration into epigenetic regulation will provide new ideas and methods to the prevention and treatment for diabetes and its complications.