中国科学院系统微生物工程重点实验室,中国科学院天津工业生物技术研究所,中国科学院系统微生物工程重点实验室,中国科学院天津工业生物技术研究所,中国科学院系统微生物工程重点实验室,中国科学院天津工业生物技术研究所
国家重点基础研究发展计划(973)(2011CBA00804),国家自然 科学基金(31070037, 31370829),天津科技支撑计划项目(11ZCZDSY08400)和国家高技术研究发展计划(863)(2012AA023402)资助项目
Key laboratory of systems microbial biotechnology, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences,Key laboratory of systems microbial biotechnology, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences,Key laboratory of systems microbial biotechnology, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences
This work was supported by grants from National Basic Research Program of China (2011CBA00804), The National Natural Science Foundation of China (31070037, 31370829), Tianjin Research Program of Application Foundation and Advanced Technology (11ZCZDSY08400) and The National Hi-Tech Research and Development Program (2012AA023402)
在各种组学及其相应的网络研究相对成熟的基础上,集成各组学网络的细胞整合型网络或全细胞网络将大大提高对生物表型的预测能力,并成为代谢工程决策的有力武器.本文在阐述了细胞工厂设计中应该考虑细胞整合网络之后,综述了细胞整合网络的重建、分析、设计方法方面的有关问题,并进一步就研究细胞整合网络涉及的数据库、软件平台、并行计算几方面的作用作了介绍.
Based on the maturity of the researches of various kinds of Omics networks, integrated cell network which integrates Omics networks will greatly improve the prediction ability of biological phenotype, and will become a powerful weapon of metabolic engineering decisions. After expounding that integrated cell network should be considered in the design of cell factory, we gave a review about reconstruction, analysis, and design methods of integrated cell network. We also introduced several aspects of databases, software platforms, parallel computing which involved in the research of integrated cell network.
徐自祥,郑平,孙际宾.全细胞网络重建与细胞工厂设计[J].生物化学与生物物理进展,2014,41(2):105-114
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