中南大学肿瘤研究所,中南大学肿瘤研究所,中南大学肿瘤研究所,中南大学肿瘤研究所,中南大学肿瘤研究所,中南大学肿瘤研究所,中南大学肿瘤研究所,中南大学肿瘤研究所
国家自然科学基金(81272298, 81372907, 81301757, 81472531, 81402009, 81528019, 81572787)和湖南省自然科学基金(14JJ1010, 2015JJ1022)资助项目
Cancer Research Institute, Central South University,Cancer Research Institute, Central South University,Cancer Research Institute, Central South University,Cancer Research Institute, Central South University,Cancer Research Institute, Central South University,Cancer Research Institute, Central South University,Cancer Research Institute, Central South University,Cancer Research Institute, Central South University
This work was supported by grants from The National Natural Science Foundation of China (81272298, 81372907, 81301757, 81472531, 81402009, 81528019, 81572787) and The Hunan Province Natural Sciences Foundation of China (14JJ1010, 2015JJ1022)
长链非编码RNA(lncRNA)是长度大于200 bp,不编码蛋白质的内源性RNA分子.近年来的研究表明,lncRNA可以作为一种竞争性内源RNA (competing endogenous RNA,ceRNA) 吸附miRNA,参与靶基因的表达调控,从而在肿瘤的发生发展中发挥重要的作用.本文从lncRNA作为ceRNA发挥生物学功能这一角度,概述了相关lncRNA在肿瘤发生发展中的作用及机制.揭秘lncRNA与miRNA在肿瘤发生中的相互作用,将为肿瘤的诊断和治疗提供新思路.
Long non-coding RNAs are defined as endogenous molecules with a length greater than 200 nucleotides and with no apparent coding potential. Recent studies showed that lncRNA could interact with the miRNA as a competing endogenous RNAs (ceRNAs) to participate in the expression regulation of target genes, which exert an importance role in the initiation and progression of tumor. In this review, based on lncRNA functioning as ceRNAs, we described the mechanism and function of some relevant lncRNA in the initiation and progression of tumor. A growing number of researches indicated that the interaction between lncRNA and miRNA in tumor genesis would provide new ideas in tumor diagnosis and treatment.
连 瑜,李夏雨,唐艳艳,杨丽婷,李小玲,熊 炜,李桂源,曾朝阳. LncRNA作为ceRNA调控肿瘤的发生发展[J].生物化学与生物物理进展,2016,43(3):219-225
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