Caspase-9选择性剪切及其在非小细胞肺癌治疗中的应用

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Caspase-9选择性剪切及其在非小细胞肺癌治疗中的应用
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作者单位:中国科学院近代物理研究所;中国科学院重离子束辐射生物医学重点实验室;甘肃省重离子束辐射医学应用基础重点实验室;中国科学院大学,中国科学院近代物理研究所;中国科学院重离子束辐射生物医学重点实验室;甘肃省重离子束辐射医学应用基础重点实验室,中国科学院近代物理研究所;中国科学院重离子束辐射生物医学重点实验室;甘肃省重离子束辐射医学应用基础重点实验室
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基金项目:国家自然科学基金重点项目(U1232207)，国家自然科学基金青年基金(11305223)，科技部重点研发计划 (2016YFC0904700)和国家科技支撑计划重点项目 (2015BAI01B11)资助

The Alternative Splicing of Caspase-9 and Its Application in Therapy of NSCLC

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Institute of Modern Physics, Lanzhou Branch Chinese Academy of Sciences;Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences;Key Laboratory of Basic Research on Heavy Ion Radiation Application in Medicine;University of Chinese Academy of Sciences,Institute of Modern Physics, Lanzhou Branch Chinese Academy of Sciences;Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences;Key Laboratory of Basic Research on Heavy Ion Radiation Application in Medicine,Institute of Modern Physics, Lanzhou Branch Chinese Academy of Sciences;Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences;Key Laboratory of Basic Research on Heavy Ion Radiation Application in Medicine

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This work was supported by grants from The Key Project of National Natural Science Foundation of China (U1232207), The National Natural Science Foundation of China(11305223), The National Key Research and Development Program of the Ministry of Science and Technology of China (2016YFC0904700), The National Key Technology Support Program of the Ministry of Science and Technology of China (2015BAI01B11)

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摘要:

越来越多的证据指出前体mRNA选择性剪切的调节在癌症病理生理学上的重要性．在非小细胞肺癌(NSCLC)的发生及发展中caspase-9 mRNA的选择性剪切发挥着重要作用，caspase-9的2个剪切异构体caspase-9a和caspase-9b的比值与NSCLC肿瘤的发生和维持密切相关，并且调节该比值关系会影响到NSCLC细胞对于抗癌治疗的敏感性．因此，caspase-9的选择性剪切是目前NSCLC治疗和诊断最受关注的焦点．本文就caspase-9的选择性剪切及其在NSCLC治疗中的应用展开综述．

Abstract:

Mounting evidence indicates the functional importance of alternative splice variations in cancer pathophysiology. The alternative splicing of caspase-9 plays an important role in non-small cell lung cancer (NSCLC). The splicing of caspase-9 gene generates two isoforms caspase-9a and caspase-9b, the ratio of caspase-9a/9b mRNA is pretty lower in a large proportion of human NSCLC tumors. A low caspase-9a/9b ratio, demanded for the tumorigenecity of NSCLC cells, is correlated with the sensitivity of NSCLC cells to anticancer therapy. Thus, the alternative splicing of caspase-9 suggests a novel and crucial distal mechanism in NSCLC and offers promise of a new target for the development of therapeutics in the defense against cancers. Therefore, this review is to summarize the alternative splicing of caspase-9 and its application in the therapy of NSCLC.

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匡彦蓓,李萍,李强. Caspase-9选择性剪切及其在非小细胞肺癌治疗中的应用[J].生物化学与生物物理进展,2017,44(4):293-302

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收稿日期:2016-09-06
最后修改日期:2017-02-27
接受日期:2017-03-01
在线发布日期: 2017-04-24
出版日期: 2017-04-20

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