综述与专论: 纳米酶的抗菌机理与应用

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综述与专论: 纳米酶的抗菌机理与应用
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作者单位:扬州大学医学院转化医学研究院,扬州大学医学院转化医学研究院,扬州大学医学院转化医学研究院,扬州大学医学院转化医学研究院
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基金项目:国家自然科学基金面上项目(81671810)和江苏省科技项目基础研究计划(自然科学基金)面上项目(BK20161333)

Reviews and Monographs: Antibacterial Mechanism and Applications of Nanozymes

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Jiangsu Key Laboratory of Experimental Translational Non-coding RNA Research,Institute of Translational Medicine,School of Medicine,Yangzhou University. 11 Huaihai Road,Yangzhou,Jiangsu Key Laboratory of Experimental Translational Non-coding RNA Research,Institute of Translational Medicine,School of Medicine,Yangzhou University. 11 Huaihai Road,Yangzhou,Jiangsu Key Laboratory of Experimental Translational Non-coding RNA Research,Institute of Translational Medicine,School of Medicine,Yangzhou University. 11 Huaihai Road,Yangzhou,Jiangsu Key Laboratory of Experimental Translational Non-coding RNA Research,Institute of Translational Medicine,School of Medicine,Yangzhou University. 11 Huaihai Road,Yangzhou

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This work was supported by grants from The National Natural Science Foundation of China (81671810) and The Basic Research Project of Natural Science Foundation of Jiangsu Province (BK20161333)

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细菌耐药性和抗生素滥用是一个世界性难题，需要开发新型抗菌剂，既能够高效杀菌，又能避免耐药性问题并具有较好的生物和环境相容性．纳米酶具有调控ROS自由基的能力，可以高效杀死多种革兰氏阳性和阴性致病菌以及顽固性生物膜；同时纳米酶具有较好的稳定性、生物相容性、可回收再利用等优点，在促进伤口愈合、龋齿防治和环境防污方面具有重要的应用前景．

Abstract:

Antibiotic-resistance of bacteria and antibiotics abuse is a global challenge. It is urgent to develop novel bactericide alternative to kill bacteria efficiently but without causing new resistance and biosafety issue. Nanozymes are nanomaterials with intrinsic enzyme-like activities which regulate reactive oxygen species (ROS) by redox reactions. This property can be used to suppress many gram-positive and gram-negative virulent bacteria and biofilms. Meanwhile, nanozymes have high stability, biocompatibility and reusability compared to other biocidal agents. Therefore nanozymes present a promising antibacterial alternative in the application of wound healing, caries prevention and marine antifouling.

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唐燕,仇智月,许卓斌,高利增.综述与专论: 纳米酶的抗菌机理与应用[J].生物化学与生物物理进展,2018,45(2):118-128

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收稿日期:2017-12-15
最后修改日期:2017-12-15
接受日期:2018-01-18
在线发布日期: 2018-02-05
出版日期: 2018-02-20

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