Nanozymes have attracted increasing attention due to their potential applications related to targeted cancer therapy, diagnostic medicine, bio-sensing and even environmental toxicology. Ferritin with unique architecture, surface properties and high biocompatibility has emerged as an excellent and promising platform for the nanozymes. To highlight the significant progress of ferritin-based nanozymes research, this review discusses the functionality of ferritin in the field of nanozymes, including ferritins as templates/nanoreactors for the synthesis of nanozymes or nanozyme-catalyzed reactions, and as carriers for the delivery of nanozymes. We also try to address the current challenges ferritin-based nanozymes being confronted and point out future directions to reveal their latent potential.