细胞/细菌驱动的药物递送系统研究进展

doi:10.16476/j.pibb.2019.0113

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细胞/细菌驱动的药物递送系统研究进展
DOI:
                        10.16476/j.pibb.2019.0113
                    
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作者单位:1.1)广东医科大学海洋医药研究院，广东医科大学药学院，广东天然药物研究与开发重点实验室，湛江 524023;2.2)中国科学院深圳先进技术研究院，中国科学院健康信息学重点实验室，广东省纳米医药重点实验室，深圳 518055
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基金项目:国家自然科学基金（81273518， 21701033， 81671758, 81601552, 81701816），广东医科大学科研基金（M2016006， B2017016），中国博士科学基金（2018M640841），“高校教育人才”组团式帮扶专项基金（4SG19057G， 4SG19045G）和广东医科大学校级学科学术带头人培育基金（4SG19003Gh）资助项目.

Review on Cell/Bacteria-Driven Drug Delivery Systems

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Affiliation:

1.1)Guangdong Key Laboratory for Research and Development of Natural Drugs, College of Pharmacy of Guangdong Medical University, Institute of Marine Medicine of Guangdong Medical University, Zhanjiang 524023, China;2.2)CAS Key of Laboratory of Health Informatics, Guangdong Key Laboratory of Nanomedicine, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China

Fund Project:

This work was supported by grants from The National Natural Science Foundation of China(81273518, 21701033, 81671758, 81601552, 81701816), Science Foundation of Guangdong Medical University(M2016006，B2017016), China PHD Science Foundation(2018M640841), “Group-type” Special Supporting Project for Educational Talents in University(4SG19057G, 4SG19045G) and School-Level Academic Leader of Guangdong Medical University(4SG19003Gh).

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摘要:

细胞/细菌驱动的药物传递系统是一种有前景的药物递送策略. 该策略将具有不同优异特性的活细胞/细菌与药物有机结合，能够有效克服传统纳米药物生物利用率低、靶向性能弱、组织穿透性不强等缺陷. 得益于对目标病灶特异响应，这类药物递送系统不仅能够实现药物高效的主动靶向递送，还可以降低对正常组织的毒副作用，目前已成功运用于药物呈递，在疾病诊断和治疗领域展示了广阔的应用前景. 本文初步探讨了细胞/细菌驱动的药物递送系统的研究进展，并对其未来研究进行展望.

Abstract:

Cell/bacteria-driven drug-delivery systems have been demonstrated as a promising drug delivery strategy. This strategy majors on kinds of inherent biocarriers combined with medicine, and effectively overcomes the shortcomings of classical nano-drug in bioavailability, targeting ability and tissue penetration. Benefitted from the specific response to the target lesion, these systems could not only achieve efficient and active targeting drug delivery, but also reduced the toxic and side effects on normal tissues. At present, these biocarriers have been widely applied in drug delivery, showing broad application prospects in the fields of accurate disease diagnosis and treatment. Here, we have reviewed the research and explore the development trend of cell/bacteria-driven drug-delivery systems.

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陈辅明,李娜,邢婕华,郑明彬,钟莹,罗英梅,马爱青,崔燎,蔡林涛.细胞/细菌驱动的药物递送系统研究进展[J].生物化学与生物物理进展,2019,46(12):1162-1170

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收稿日期:2019-05-20
最后修改日期:2019-11-06
接受日期:2019-11-14
在线发布日期: 2020-04-23
出版日期: 2019-12-20

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