1.1)膜生物学国家重点实验室,北京大学分子医学研究所,北京心血管代谢分子医学重点实验室,北京 100871;2.2)北京-清华生命科学联合中心,北京 100871;3.3)北京大学前沿交叉学院,北京 100871
Tel:
中国科技部重点研发计划(2016YFA0502004),国家自然科学基金(91957201,31622021,31870833 和31821091),北京市自然科学基金(5192009)和千人计划资助项目.
1.1)State Key Laboratory of Membrane Biology, Institute of Molecular Medicine, Peking University, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Peking University, Beijing 100871, China;2.2)Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China;3.3)Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China
This work was supported by grants from the Ministry of Science and Technology of China (2016YFA0502004), The National Natural Science Foundation of China (91957201, 31622021, 31870833, 31821091), Beijing Natural Science Foundation (5192009) and Young Thousand Talents Program of China.
高渗促钙内流蛋白(hyperosmolality-induced [Ca2+]i increase,OSCA)/跨膜蛋白63(transmembrane protein 63,TMEM63)家族蛋白是一类多次跨膜蛋白质,它们在真核细胞中有广泛分布. 研究表明拟南芥中OSCA1.1蛋白介导了高渗刺激的钙离子内流. 进一步研究发现OSCA1.1及其同源蛋白质是机械力敏感的离子通道. 高分辨率冷冻电镜结构显示OSCA蛋白是对称的二聚体,每个亚基含有一个离子可通透的孔道. 本文将从OSCA通道的功能、结构以及结构与功能的关系几方面介绍该领域的研究进展.
Hyperosmolality-induced [Ca2+]i increase (OSCA)/Transmembrane protein 63 (TMEM63) family proteins are multi-pass membrane proteins. They are broadly presented in eukaryotic cells. Previous study showed that OSCA1.1 from Arabidopsis mediated the hyperosmolality induced calcium increase in plants. Additional studies showed OSCA1.1 and its homologues were mechanosensitive ion channels. High resolution cryo-EM structures revealed that OSCA proteins were symmetric dimers and each subunit harbored an ion permeation pathway. The review will focus on recent progress on the studies of the function, structure and structural-functional relationship of OSCA channels.
吴惊香,陈雷. OSCA/TMEM63家族离子通道的研究进展[J].生物化学与生物物理进展,2020,47(2):123-130
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