间歇性θ节律经颅磁刺激改善大鼠工作记忆的海马与前额叶跨脑区神经网络效应研究
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河北工业大学电气工程学院,省部共建电工装备可靠性与智能化国家重点实验室,天津市生物电工与智能健康重点实验室,天津 300130

作者简介:

郭苗苗 Tel: 15900241399, E-mail: gmm@hebut.edu.cn徐桂芝 Tel: 13072222266, E-mail: gzxu@hebut.edu.cnGUO Miao-Miao. Tel: 86-15900241399, E-mail: gmm@hebut.edu.cnXU Gui-Zhi. Tel: 86-13072222266, E-mail: gzxu@hebut.edu.cn

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基金项目:

国家自然科学基金(51737003,51677053,51707054)和天津市自然科学基金(20JCQNJC00710)资助项目。


Effect of Intermittent Theta Burst Stimulation on Cross-brain Neural Network Between The Hippocampus and Prefrontal Cortex of Working Memory in Rats
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Affiliation:

School of Electrical Engineering, State Key Laboratory of Reliability and Intelligence of Electrical Equipment, Tianjin Key Laboratory of Bioelectromagnetic Technology and Intelligent Health, Hebei University of Technology, Tianjin 300130, China

Fund Project:

This work was supported by grants from The National Natural Science Foundation of China (51737003, 51677053, 51707054) and the Natural Science Foundation of Tianjin, China (20JCQNJC00710).

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    摘要:

    目的 间歇性θ节律刺激(iTBS)作为一种新型的经颅磁刺激模式,已经广泛应用于探索大脑认知功能和神经调控等方面,但其电生理调控机制尚不清晰,探索iTBS对大脑认知功能的影响及其电生理机制,对脑疾病的治疗和磁刺激的临床应用具有重要意义。方法 本文利用iTBS制备磁刺激大鼠模型,采集记录大鼠在执行工作记忆(WM)任务过程中腹侧海马(vHPC)和内侧前额叶皮层(mPFC)的局部场电位(LFPs)信号,应用格兰杰因果网络分析方法,研究了iTBS对大鼠WM过程中vHPC与mPFC跨脑区神经网络协同和信息交互的影响。结果 iTBS增强了大鼠的学习记忆能力,使其完成工作记忆任务所需时长减少(2.67±1.63)d(P<0.05),iTBS显著改善了大鼠的行为学表现;同时iTBS增强了大鼠在WM期间vHPC与mPFC脑区的自因果网络连接,增加了网络连接强度、连接密度和全局效率(P<0.05);并且iTBS增强了vHPC与mPFC脑区的跨脑区网络连接,增加了vHPC-mPFC跨脑区的节点度和因果流向(P<0.05)。结论 iTBS磁刺激对大鼠工作记忆行为学及相关脑区神经网络均有显著的积极作用,iTBS可以促进大鼠认知能力,提高大脑神经网络的信息交互和传递效率,iTBS的神经调控机制可能是通过增强大脑vHPC与mPFC之间的网络连接和信息交互来提高工作记忆能力。

    Abstract:

    Objective As a new type of transcranial magnetic stimulation, the intermittent theta burst stimulation (iTBS) has been widely used to explore brain cognitive function and neuroregulation, but its electrophysiological regulation mechanism is still unclear. Therefore, exploring the underlying electrophysiological mechanism and the effect of iTBS on the brain’s cognitive functions is of great significance for the treatment of brain diseases and clinical application of magnetic stimulation.Methods In this study, the model rats were treated with iTBS, and the local field potential (LFPs) signals in the ventral hippocampus (vHPC) and medial prefrontal lobe (mPFC) were collected and recorded during the working memory (WM) tasks in rats. The effect of iTBS on neural network coordination and information interaction across brain regions was investigated by using Granger causality network.Results The results suggested that iTBS enhanced the WM ability and the behavioral performance of the rats, reducing the time to complete the WM task by (2.67±1.63) d (P<0.05). At the same time, iTBS enhanced the self-causal network connections in vHPC and mPFC during WM, and increased the network connection strength, connection density and global efficiency (P<0.05). In addition, iTBS enhanced the cross-brain network connection between vHPC and mPFC, and increased the node degrees and causal flow (P<0.05) from vHPC to mPFC.Conclusion iTBS has a significant positive effect on the behavior of WM and neural network in related brain areas of rats. iTBS can promote the cognitive ability of rats and improve the efficiency of information interaction and transmission of neural network. The neural regulation mechanism of iTBS may be to enhance the WM ability by enhancing the network connection and information interaction between vHPC and mPFC.

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张天恒,郭苗苗,徐桂芝,吉利辉,王中豪.间歇性θ节律经颅磁刺激改善大鼠工作记忆的海马与前额叶跨脑区神经网络效应研究[J].生物化学与生物物理进展,2022,49(8):1573-1585

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历史
  • 收稿日期:2021-08-18
  • 最后修改日期:2022-07-28
  • 接受日期:2021-12-21
  • 在线发布日期: 2022-08-19
  • 出版日期: 2022-08-20