PANoptosis is a form of programmed cell death that integrates features of pyroptosis, apoptosis, and necroptosis. The core mechanism underlying PANoptosis involves the assembly and activation of the PANoptosome, a multi-protein complex. This process is regulated by key upstream molecules such as interferon regulatory factor 1 (IRF1), transforming growth factor beta-activated kinase 1 (TAK1), and adenosine deaminase acting on RNA 1 (ADAR1), and is influenced by various organelle functions. Targeting the regulatory mechanisms of PANoptosis represents a promising therapeutic approach for modulating this form of cell death. Inflammation is known to play a pivotal role in cardiovascular diseases. Given the highly pro-inflammatory nature of PANoptosis, investigating its contribution to cardiovascular pathophysiology is of great importance. This review summarizes the existing evidence on PANoptosis in cardiovascular diseases, including myocardial ischemia/reperfusion injury, myocardial infarction, heart failure, arrhythmogenic cardiomyopathy, sepsis-induced cardiomyopathy, cardiotoxic injury, atherosclerosis, abdominal aortic aneurysm, thoracic aortic aneurysm and dissection, and vascular toxic injury. Understanding the role of PANoptosis in these conditions is crucial for advancing clinical knowledge and developing therapeutic strategies for cardiovascular disease pathophysiology.