Oxidatively modification of low density lipoprotein(LDL) could contribute to theatherosclerotic process by its cytotoxic effect,e.g.being uptaked by the macrophage sca-venger receptor,accelerating the foam cell formation and the influencing on monocyte andmacrophage mobility.The aim of present study is to examine the effect of different con-centrations of vitamine C on Cu²⁺-induced oxidative modification of LDL.As evidencedby the lipid peroxide content,lipofusion and the elec trophoretic mobility,vitamine C could inhibit the oxidative modification of LDL for 24h. The extent of the inhibition depended on vitamine C concentration. These findings indicate that vitamine C is a potentantio-xidant in vivo, it can protect LDL from oxidative modification. Hence, vitamine C can prevent and treat atherosclerosis.