Human erythropoietin receptor (hEPOR) is a transmembrane protein which located in the surface of the relatively mature erythroid progenitor cells. It can promote the viability,proliferation and differentiation of the cells by specifically binding to erythropoietin(EPO),in which process the hEPOR itself and some other proteins will be phosphorylated. There are some conserved domains in hEPOR which is adapted to its function,The amino acid sequence of the human EPOR is 82% identical to that of the mouse protein. The EPOR can be constitutively activated by a single R129C mutation or binding to a special protein. It is also closely related to many blood diseases such as erythroleukemia.